Saturday, March 31, 2012

Before You Start a Home Based Business Online | Affiliate Marketing ...

Article by Larry Haywood There is a constant stream of advertisements and information coming across the Internet, aimed at individuals who want to know how to start a home based business online. The theme of these advertisements is that this is an opportunity that?s too good to pass on. If you are hardworking, committed to?

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harddaysbitemovie.com - Any Local Organization Internet Promotion ...

Marketing and advertising your organization on the web is dependant on demonstrating which you have a thing to offer you your visitors that your competition do not need. Marketing and advertising your small business on the web suggests calling your own clients along with prospective customers and establishing by yourself apart.
Prosperous small business Affiliate marketing is dependant on setting up human relationships. Equally clients within your physical retailer have a chance to return in and get to know you, on the web clients have to be because of the probability for more information on that which you do also to choose that they gotta have pu erh to do business with you.
That?s where the idea of your tiny biz online marketing direct can be purchased in. Your tiny biz online marketing direct is usually a strategies which you?ll ? over time ? find potential customers and increase your small business profits.
Your tiny biz online marketing direct is just not contrary to a nearby small business marketing that you just began when you started out your organization to use strategic location. Only wire is had to decide on a position also to have that position completely ready. You requested the provides you possessed. You then started promotion. On beginning day, the chances are you needed something free gift ? a keychain, a mug or maybe even a capital t-clothing ? and also a token free gift, something that would encourage your customer to come back.
Your tiny biz online marketing direct operates in similarily: you decide a domain name and make your blog, or have your blog produced for you. You?re going to get all which you will want so as ? including a absolutely free or minimal-expense free gift. And you then will become marketing your small business on the web.
You will need to understand that your website is your personal organization. Every one of the tapetsering stockholm Net advertising?s that you just put brings people to your website, so you should definitely make use of the website properly.
Occurs home page to tell prospective customers relating to your organization ? discuss your mission report, discuss customer words of flattery. Utilize a website within your website to permit your own and prospective customers uncover more about what you do and what you believe in. Concentrate both equally on your own organization and so on setting up a romantic relationship with your customer.
Attracting prospective customers in aimed at your site gives them into the biggest part of your tiny biz online marketing direct permitting them to be able to get to know you sets out to lure them into the direct.
Even so, you don?t want them to make it on the subsequent volume of the direct and remain there, equally as you don?t want clients for your strategic location to run in and move then back out again. This is the reason you should system ? with your small business Affiliate marketing promotion ? to draw them into the upcoming tiniest subject of your tiny biz online marketing direct.
It is not ne

cessary to provide a physical free gift. Instead, continue to keep engage with your website visitors by offering them a thing of worth. Present them absolutely free articles about services and products that your small business features. Put in place a e-newsletter that will let you speak useful facts (along with deals) directly to them at given times.
Doing so helps you consider a significant measure to escalating profits: it helps you establish a relationship. By constantly supplying your clients with facts or discount coupons which can be useful directly to them, they will quickly understand anyone with a organization like a organization that they want to do business with, and they can count on hearing from you.
It is also possible to really encourage them to do business with you by promoting minimal-expense entry-ending solutions. Now, instead of a free article giving your prospective customers a small amount of binary options demo account facts, using them as your own clients by offering minimal-expense solutions. Small-expense entry-ending solutions for instance electronic-publications that provide beneficial details about important subject areas inside your industry ? and further create your standing as well as consumers? have faith in ? will help to lure those clients as a result of the particular volume of your tiny biz online marketing direct.
As an example, let?s pretend you buy and operate any local flowery shop. A perfect minimal-expense entry-ending facts solution you can offer you for your clients to draw them even more into the profits direct can be an electronic-ebook with sowing approaches for expanding plants nearer your home. Prospects who purchase minimal-expense electronic-ebook will quickly realize importance inside facts, increasing the chance that they need to pay for extra, more costly solutions from you at the same time.
A final volume of your tiny biz online marketing direct the place that you might want your own clients to generally be: oahu is the phase wherever your absolutely free and minimal-expense entry-ending merchandise, together with your news letters and other marketing, increases profits within your substantial-expense, back-ending services and products.
This can be a objective of your small business Affiliate marketing: to find prospective customers, establish a relationship and increase profits. To recap, your tiny biz online marketing direct operates this way:
u Develop and Promote Your Website to Draw in Potential Clients
u Participate the potential Shopper
u Identify Believe in by using a Free gift
u Create a relationship by using a e-newsletter and deals
u Really encourage tiny, minimal-expense entry-ending profits
u Make the large-ticket profits within your services and products
So as to, and also continuous to promote your web site to new prospective customers, you will appreciate that your little friend biz online marketing direct is usually a method that lets you constantly and easily get potential customers and increase profits for your small business.
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Skin Care And Acne Products For Dry And Oily ... - Health and Fitness

Healthy skin is not just about looking excellent. As a matter of fact, our skin is the largest organ in our body. It helps protect us against bacteria and infection. If our skin were unhealthy or hurt, our bodies would be susceptible to all kinds of tribulations.

The best skin care for you will depend largely on your type of skin. There are three basic types of skin, but this article will focus on only two.

Identify your Skin Type

This is the way to determine what type of skin you have. Firstly, you should wash your face with a skin filter, rinse and then pat dry. Wait for an hour and pay special attention to how your skin reacts. In essence, try and see whether your skin feels tight or not.

Next, push a break piece of tissue paper on: the outer part of you cheeks, your chin, the center of your cheeks, your nose, the center of your forehead and the outer part of your forehead. Look at the tissue and check for oily residue or flaky skin residue.

You?re considered to have dry skin if each tissue paper has flaky skin residue. If each piece of tissue paper has oily residue, then you are considered to have oily skin. Once you know this, you will be better equipped to pick your skin care routine, skin products and acne products.

Skin Care Tips for Dry and Oily Skin

You should be careful when treating dry skin. Products that contain fragrances and other fillers usually irritate dry skin. This is why it is a excellent thought to stay away from these types of products.

When treating dry skin you should use a cream or oil filter followed by a moisturizer. Exfoliation is also an vital step for dry skin. You can exfoliate by using natural products such as milk or grape juice for a gentler exfoliation.

Oily skin care also requires cleansing, exfoliating, and moisturizing. Foaming cleansers work the best for this type of skin. The best type of treatment for this skin type are mechanical exfoliators and water-based moisturizers.

The Best Acne Products for Dry and Oily Skin

Both oily skin and dry skin types can suffer from acne. The best acne creams for each contain different ingredients especially catered to each skin type?s necessities.

Oily skin is more capable of withstanding the harsher ingredients in most traditional acne products. To control acne in these skin types, make sure that your acne products contain salicylic acid, retinoids and/or benzoyl peroxide. These ingredients help control surplus sebum production, clogged pores and acne bacteria.

When treating dry skin, remember that it must be stay adequately moisturized in order to help control acne tribulations. Non-comedogenic oils that won?t irritate your skin are castor oil and lime oil. But, instead of products containing benzoyl peroxide, try using creams that contain tea tree oil.

For acne skin care to be successful, it must be catered to each type of skin. Products like BIOSKINCLEAR and BIOACNECARE are brilliant treatments for acne because they are gentle yet effective.

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Once considered mainly 'brain glue,' astrocytes' power revealed

Friday, March 30, 2012

A type of cell plentiful in the brain, long considered mainly the stuff that holds the brain together and oft-overlooked by scientists more interested in flashier cells known as neurons, wields more power in the brain than has been realized, according to new research published today in Science Signaling.

Neuroscientists at the University of Rochester Medical Center report that astrocytes are crucial for creating the proper environment for our brains to work. The team found that the cells play a key role in reducing or stopping the electrical signals that are considered brain activity, playing an active role in determining when cells called neurons fire and when they don't.

That is a big step forward from what scientists have long considered the role of astrocytes ? to nurture neurons and keep them healthy.

"Astrocytes have long been called housekeeping cells ? tending to neurons, nurturing them, and cleaning up after them," said Maiken Nedergaard, M.D., D.M.Sc., professor of Neurosurgery and leader of the study. "It turns out that they can influence the actions of neurons in ways that have not been realized."

Proper brain function relies on billions of electrical signals ? tiny molecular explosions, really ? happening remarkably in sync. Recalling the face of a loved one, swinging a baseball bat, walking down the street ? all those actions rely on electrical signals passed instantly along our nerves like a molecular hot potato from one brain cell to another.

For that to happen, the molecular brew of chemicals like sodium, calcium and potassium that brain cells reside in must be just right ? and astrocytes help to maintain that balanced environment. For instance, when a neuron sends an impulse, or fires, levels of potassium surrounding the cell jump dramatically, and those levels must come down immediately for the brain to work properly. Scientists have long known that that's a job for astrocytes ? sopping up excess potassium, ending the nerve pulse, and restoring the cells so they can fire again immediately.

In the paper in Science Signaling, Nedergaard's team discovered an expanded role for astrocytes. The team learned that in addition to simply absorbing excess potassium, astrocytes themselves can cause potassium levels around the neuron to drop, putting neuronal signaling to a stop.

"Far from only playing a passive role, astrocytes can initiate the uptake of potassium in a way that affects neuronal activity," said Nedergaard. "It's a simple, yet powerful mechanism for astrocytes to rapidly modulate neuronal activity."

Nedergaard has investigated the secret lives of astrocytes for more than two decades. She has shown how the cells communicate using calcium to signal. Nearly 20 years ago in a paper in Science, she pioneered the idea that glial cells like astrocytes communicate with neurons and affect them. Since then, has been a lot of speculation by other scientists that chemicals call gliotransmitters, such as glutamate and ATP, are key to this process.

In contrast, in the latest research Nedergaard's team found that another signaling system involving potassium is at work. By sucking up potassium, astrocytes quell the firing of neurons, increasing what scientists call "synaptic fidelity." Important brain signals are crisper and clearer because there is less unwanted activity or "chatter" among neurons that should not be firing. Such errant neuronal activity is linked to a plethora of disorders, including epilepsy, schizophrenia, and attention-deficit disorder.

"This gives us a new target for a disease like epilepsy, where signaling among brain cells is not as controlled as it should be," said Nedergaard, whose team is based in the Division of Glia Disease and Therapeutics of the Center for Translational Neuromedicine of the Department of Neurosurgery.

The first authors of the paper are Fushun Wang, Ph.D., research assistant professor of Neurosurgery; and graduate student Nathan Anthony Smith. They did much of the work by using a sophisticated laser-based system to monitor the activity of astrocytes in the living brain of rats and mice. The work by Smith, a graduate student in the University's neuroscience program, was supported by a Kirschstein National Research Service Award from the National Institute of Neurological Disorders and Stroke (NINDS).

Other authors from Rochester include Takumi Fujita, Ph.D., post-doctoral associate; Takahiro Takano, Ph.D., assistant professor; Qiwu Xu, technical associate; and Lane Bekar, Ph.D., formerly research assistant professor, now at the University of Saskatchewan. Also contributing were Akemichi Baba of Hyogo University of Health Sciences in Japan, and Toshio Matsuda of Osaka University in Japan.

Nedergaard notes that the complexity and size of our astrocytes is one of few characteristics that differentiate our brains from rodents. Our astrocytes are bigger, faster, and much more complex in both structure and function. She has found that astrocytes contribute to conditions like stroke, Alzheimer's, epilepsy, and spinal cord injury.

"Astrocytes are integral to the most sophisticated brain processes," she added.

The latest paper caps a remarkable run for the Nedergaard group. In two months the team has published a paper on adenosine in the Proceedings of the National Academy of Sciences, a paper on spinal cord injury in the Journal of Neuroscience, and two papers in Science Signaling on communication between neurons and astrocytes.

###

University of Rochester Medical Center: http://www.urmc.rochester.edu

Thanks to University of Rochester Medical Center for this article.

This press release was posted to serve as a topic for discussion. Please comment below. We try our best to only post press releases that are associated with peer reviewed scientific literature. Critical discussions of the research are appreciated. If you need help finding a link to the original article, please contact us on twitter or via e-mail.

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Essential Information About American Communications Network ...

communication networks

ACN Inc Secte is an international leading company that originated in the United States of America. The company was built in January 1993. As of the record, the company has been serving total of 24 countries in different continents. Among the continents they are serving are Asia, Pacific, Europe, and North America. The company mainly focuses in offering services to valued clients who are spending and using money in any ways. The company was personally endorsed by the famous Donald Trump. Matter of fact, the company was featured on The Celebrity Apprentice. It was also featured on the Wall Street Journal, USA Today, and a lot more.

As of today, American Communications Network is one of the largest direct selling telecommunication services in the globe. The company is the most sought after telecommunication provider. They know what their clients want. They offer services that would best suit the needs of the customers at a very reasonable rate. The best thing about the company is that they let the consumer choose their own plan. Not only that they are giving excellent service, but they are also offering great compensation package. You will be able to make money through commissions and other reward points.

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Train Horn Pranks - General Chat - =ADK= Gaming Community

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Eurozone inflation falls by less than predicted

(AP) ? Inflation in the 17 countries that use the euro did not fall as much as predicted during March, in a further sign that rising oil prices are having an impact on the countries' economies.

Figures from Eurostat, the EU's statistics office, showed inflation in the eurozone in the year to March fell to 2.6 percent from 2.7 percent the previous month.

The decline was not as big as predicted. The consensus in the markets was for the rate to fall to 2.5 percent.

Inflation in the eurozone remains above the European Central Bank's target of keeping price rises just below 2 percent. That suggests that the ECB has less room to cut interest rates further if it wanted to. It meets again next week and the expectation is that the benchmark interest rate will be maintained at 1 percent.

Rising oil prices in recent weeks have raised concerns that inflation may not fall below target as quickly as hoped.

Associated Press

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FirstMark Capital Leads $7.5M Round In Social Shopping Startup Sneakpeeq

sneakpeeqSneakpeeq, a social shopping startup that debuted at TechCrunch Disrupt last year, has raised $7.5 Million in Series A funding led by FirstMark Capital with participation from existing investors Bain Capital Ventures and Metamorphic Ventures. This brings the company's total funding to over $10 million. The startup aims to replicate the experience of shopping for items in a retail store with a social twist. Similar to the way you flip over a price tag to look at the cost of at item at a store, Sneakpeeq doesn't tell you the price instantly when you visit a product's landing page. You click a "Peeq" button to find the price. The site features daily boutiques that offer discounts on clothes, shoes, home accessories and more from 1000-plus brands, from well-known names like Kate Spade and Puma to smaller designers and purveyors.

Source: http://feedproxy.google.com/~r/Techcrunch/~3/rUQpu6ke6CI/

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Friday, March 30, 2012

A Rosie Future: Jetsons -Like Gadgets with "Ambient Intelligence" Are Key to Smart Homes and Cities

News | Technology

Information collected by AI software from sensors in homes and cities could identify and address health, safety and environmental problems without human intervention


artificial intelligence, robot, sensor, city, networkAMBIENT INTELLIGENCE: Advances in artificial intelligence, sensor networks and robotics will not only draw data from smart phones, traffic signals and various other sources. The technology will also, without being asked, take action based on this information. Image: Courtesy of Kalawin Jongpo, via iStockphoto.com

Fifty years after The Jetsons promised us a future of robot maids, flying cars, video phones and meals at the push of a button, it seems that reality may actually surpass this futuristic vision. By 2062, the year the animated show was set, advances in artificial intelligence, sensor networks and robotics promise to make the Jetsons's home in Skypad Apartments, and indeed in all of Orbit City, seem quaint by comparison (although flying cars may remain out of reach?especially ones that beat parking problems by folding into a suitcase).

Many of today's homes in the developed world already include a lot of the sensors and networking devices needed to make the smart home a reality, wrote Diane Cook, a professor in Washington State University's School of Electrical Engineering and Computer Science, in the March 30 issue of the journal Science. The home of the future will harness information from appliances, computers, smart phones and other devices to intuitively meet the needs of its residents. Computer software will play the role of an intelligent agent by perceiving the state of a home's physical environment and residents via sensors, interpreting this information using artificial intelligence, and automatically adjusting heating or cooling, lighting or other resources based on that information.

Cook refers to artificial intelligence and data-mining technologies' ability to seek useful information on resident behavior and the state of the home, and to automatically act on this information, as "ambient intelligence." It will foremost be used to monitor the health of a smart home's inhabitants and to maximize energy efficiency as well as facilitate communication both within the household and with the outside world.

For the past year Cook and her colleagues have been studying the potential of smart-home technology to enable residents at the Horizon House retirement community in Seattle to extend the time they are able to live independently. A year ago the researchers installed dozens of sensors in some residents' apartments to monitor motion, energy use and other conditions. Whereas half of the study participants have mild cognitive problems, the rest are healthy.

The researchers are using data collected to test the activity-recognition algorithms used by their software. "Our clinical psychology collaborators visit the residents every six months to perform a complete cognitive and physical health battery of tests," Cook says. "We are currently designing techniques to identify correlations between behavioral changes and cognitive and physical health changes." She expects to report on initial findings as early as this summer.

Increasingly, smart homes will exist within smart cities that likewise connect citizens via ambient intelligence. Such cities will integrate data from a variety of different sensors placed to record information about factors important to daily life?including air quality, traffic and weather?and then initiate some action if needed. Examples would be adjusting the timing of traffic signals to improve traffic flow or texting alerts to city dwellers warning them to stay indoors due to poor air quality.

Of course for a smart city to work, diverse data sources must be mined in a way that respects the privacy of its citizens. University College Dublin researchers Michael O'Grady and Gregory O'Hare raise the issue of "ambient law" in a related Science article on the emergence of smart cities. "To harness ambient intelligence, users must be prepared to share some knowledge about themselves?and this brings risks," O'Grady says. "Once a technology begins to leave the lab, it is essential that legal, privacy and ethical issues be considered."

Ambient law takes into account that the freedoms protected by a constitutional democracy may be radically altered as ambient intelligence permeates everyday life, O'Grady and O'Hare argue in their article. To avoid the loss of privacy and other freedoms, the legal community must work with computer scientists to establish rules that must be coded into ambient technologies before they become intrusive or damaging to individuals' privacy.

Now, if researchers could only find a way to make George Jetson's nine-hour workweek part of our future, too.

Source: http://rss.sciam.com/click.phdo?i=7ae68978f5ba06a218c6d5a835fcc030

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Thursday, March 29, 2012

Toward a test strip for detecting TNT and other explosives in water

ScienceDaily (Mar. 28, 2012) ? Scientists have described development of a new explosives detector that can sense small amounts of TNT and other common explosives in liquids instantly with a sensitivity that rivals bomb-sniffing dogs, the current gold standard in protecting the public from terrorist bombs. They reported on the technology, suitable for incorporation into a TNT test strip, at the 243rd National Meeting & Exposition of the American Chemical Society (ACS), being held in San Diego the week of March 26.

The sensor also has potential uses in detecting water pollution involving TNT, according to Yu Lei, Ph.D., and Ying Wang, who developed the sensor. Such contamination can occur from production, obsolete storage facilities and other sources. TNT contamination of drinking water carries a risk of serious health disorders.

Wang, a graduate student in Lei's laboratory at the University of Connecticut, said there has been a long-standing need for a fast, simple, accurate way to detect so-called "nitroaromatic compounds" in salt water, fresh water and other liquids. That family of compounds includes 2,4,6-trinitrotoluene -- TNT -- which is so widely used in construction, agriculture and military applications that it has become the standard for measuring explosive force, even for nuclear weapons.

"Law enforcement or homeland security officials concerned about the presence of TNT in a harbor at docks need an answer quickly so they can take steps to protect people and property," Wang pointed out. "That's not easy with traditional testing methods."

Those tests involve taking a sample of water and shipping it to a full-scale laboratory. The sample must be concentrated because water currents dilute the explosive, leaving only minute amounts in the sample. And water samples must be prepared in other ways before analysis with expensive laboratory instruments.

"Our new sensor promises to provide answers on-the-scene almost immediately," Wang added, noting that it is based on a color change that occurs when a sensing molecule in the device attaches to an explosive. Lei explained that the device can detect very small amounts of TNT, as well as larger amounts. The broad sensing range, high sensitivity and dual action make this new sensor unique among those that work on water-based samples, he noted.

So far, Lei and Wang have been able to detect concentrations of explosives, such as TNT, ranging from about 33 parts per trillion (equivalent to one drop in 20 Olympic-sized swimming pools) to 225 parts per million.

Lei and Wang explained that the sensor is already easy to use, but they plan to make it even more user-friendly by incorporating it into a paper strip, similar to the test strips used to test for pregnancy. That way, an explosives expert or airport screener would simply dip the filter paper into a sample of ocean water or other liquid, and put that filter paper into a machine that would read the fluorescence and detect the presence of explosives in real time. The sensor also could be used to detect TNT that leaches into the environment, in streams or rivers near munitions testing sites and manufacturing facilities.

The scientists acknowledged funding from the National Science Foundation.

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Source: http://feeds.sciencedaily.com/~r/sciencedaily/~3/f6JzEsp5Qfw/120328154429.htm

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Android 4.0.4 rears its head again, this time over at AOSP

Image
It hasn't made its official open-source debut yet, but Android 4.0.4 should be hitting the repositories very soon. Leaks of the next Ice Cream sandwich update have been circulating since early February, and Moto's Xoom was given the first taste today. Now Jean-Baptiste Queru, an engineer on the mobile OS, has posted over at the Android Open Source Project forums to let us know that the appropriate files are being pushed as we speak. Of course, this doesn't mean that 4.0.4 will hit your handset any time soon... or ever, for that matter. But, it does mean that more custom ROM devs will be incorporating its pile of bug fixes into their products. Watch the source links to be alerted the moment it goes live.

Android 4.0.4 rears its head again, this time over at AOSP originally appeared on Engadget on Wed, 28 Mar 2012 15:41:00 EDT. Please see our terms for use of feeds.

Permalink Android Central  |  sourceAOSP 1, 2  | Email this | Comments


Source: http://feeds.engadget.com/~r/weblogsinc/engadget/~3/u0ZSv7DCes8/

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Syrian violence ignores peace diplomacy

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Source: http://news.yahoo.com/annan-says-syria-accepts-peace-plan-u-skeptical-073910459.html

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Wednesday, March 28, 2012

Sales Coaching and How You Can Improve Business

Sales training involves identifying problems before solving them. After all, knowing a problem is the first step in solving it. When it comes to sales training, an entrepreneur?s goal is to improve the development of the enterprise by first looking out for any faults the business might have.

Any entrepreneur can apply for sales training to learn how to look out for their own flaws, which flaws to look out for, and how to work on them. This is akin to editing a written work. You look at the entire article and tweak its flaws to turn it into something better. Business is like art in this way; you may do well, but there can always be some points where you can do better.

But how can you find your mistakes? There will always be subtle shortcomings in how the business is operating.

You may prompt feedback from your consumers with little feedback ballots or make employees evaluate their managers and vice-versa.

The information you receive can serve as a marker for which points in the business you can improve on. You might be surprised that there could be some aspects in the business that needs a little tuning up. It could be the attitude of your employees or the marketing of your business. In any case, you may apply for sales training to learn how to refine faulty places.

Improving the way you run your business can require some sales training if you really want to excel. It is true that education and learning continues beyond school: you continue to learn things about yourself or your world that you did not know before. After this, you?ll be ready to march back to your business site and tighten the way you run your ship, so to speak.

Aesthetics, marketing, and consumer relationship are the three aspects of business that you might already know by the time you decided to establish your business. Sales training courses can also add something to help internal management: how you establish rapport with subordinates can greatly affect the success of the business. Establishing a clear and respectful professional relationship with the people in the company brings out the importance of teamwork.

Sales training programs also teach business owners to manage finances. This helps business owners cut down on unnecessary expenses while gathering more revenue than before. For more information on sales training, visit SellingToConsumers.com or SalesTrainingAdvice.com.

Source: http://business.ezinemark.com/sales-coaching-and-how-you-can-improve-business-7d351b6907c6.html

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Small Business Branding is REALLY Important - Forte Marketing ...

By Jamie Warren on March 27, 2012 ? 8:00 am

That?s our answer to Forbes when they ask, ?How important is small business branding really?? in this recent article.

In it, the author shares five strategies for creating brand recognition. We think these are great, but we would add one additional one:

  • Be prepared to look at your market, your customers, your product and adjust your branding as needed.

Branding is a living thing ? it needs to be nurtured to be successful. If, every day, you think of all your decisions with the company?s brand in mind, you?ll ensure your brand is up to date with other factors in your business.

Forte Marketing Group is a Birmingham, Alabama-based branding, marketing and advertising firm that helps companies nationwide differentiate their brands. Learn more about us at www.fortemg.com.

Source: http://fortemg.com/small-business-branding-is-really-important/

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Time to turn the screw, Fergie tells United

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Source: http://news.yahoo.com/time-turn-screw-fergie-tells-united-000236824.html

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Celebrate Free Card Day with FX Photo Studio for iPhone

The popular photo filter iPhone app, FX Photo Studio, has recently partnered with Sincerely to include the ability to send physical postcards from directly within the app. For today only, they're allowing users to order one card for free!


Source: http://feedproxy.google.com/~r/TheIphoneBlog/~3/ZzZWgqgryGA/story01.htm

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Tuesday, March 27, 2012

Genetic risk and stressful early infancy join to increase risk for schizophrenia

Genetic risk and stressful early infancy join to increase risk for schizophrenia [ Back to EurekAlert! ] Public release date: 26-Mar-2012
[ | E-mail | Share Share ]

Contact: Vanessa McMains
cmain1@jhmi.edu
410-502-9410
Johns Hopkins Medical Institutions

Human genome and mouse studies identify new precise genetic links

Working with genetically engineered mice and the genomes of thousands of people with schizophrenia, researchers at Johns Hopkins say they now better understand how both nature and nurture can affect one's risks for schizophrenia and abnormal brain development in general.

The researchers reported in the March 2 issue of Cell that defects in a schizophrenia-risk genes and environmental stress right after birth together can lead to abnormal brain development and raise the likelihood of developing schizophrenia by nearly one and half times.

"Our study suggests that if people have a single genetic risk factor alone or a traumatic environment in very early childhood alone, they may not develop mental disorders like schizophrenia," says Guo-li Ming, M.D., Ph.D., professor of neurology and member of the Institute for Cell Engineering at the Johns Hopkins University School of Medicine. "But the findings also suggest that someone who carries the genetic risk factor and experiences certain kinds of stress early in life may be more likely to develop the disease."

Pinpointing the cause or causes of schizophrenia has been notoriously difficult, owing to the likely interplay of multiple genes and environmental triggers, Ming says. Searching for clues at the molecular level, the Johns Hopkins team focused on the interaction of two factors long implicated in the disease: Disrupted-in-Schizophrenia 1 (DISC1) protein, which is important for brain development, and GABA, a brain chemical needed for normal brain function.

To find how these factors impact brain development and disease susceptibility, the researchers first engineered mice to have reduced levels of DISC1 protein in one type of neuron in the hippocampus, a region of the brain involved in learning, memory and mood regulation. Through a microscope, they saw that newborn mouse brain cells with reduced levels of DISC1 protein had similar sized and shaped neurons as those from mice with normal levels of DISC1 protein. To change the function of the chemical messenger GABA, the researchers engineered the same neurons in mice to have more effective GABA. Those brain cells looked much different than normal neurons, with longer appendages or projections. Newborn mice engineered with both the more effective GABA and reduced levels of DISC1 showed the longest projections, suggesting, Ming said, that defects in both DISC1 and GABA together could change the physiology of developing neurons for the worse.

Meanwhile, other researchers at University of Calgary and at the National Institute of Physiological Sciences in Japan had shown in newborn mice that changes in environment and routine stress can impede GABA from working properly during development. In the next set of experiments, the investigators paired reducing DISC1 levels and stress in mice to see if it could also lead to developmental defects. To stress the mice, the team separated newborns from their mothers for three hours a day for ten days, then examined neurons from the stressed newborns and saw no differences in their size, shape and organization compared with unstressed mice. But when they similarly stressed newborn mice with reduced DISC1 levels, the neurons they saw were larger, more disorganized and had more projections than the unstressed mouse neurons. The projections, in fact, went to the wrong places in the brain.

Next, to see if their results in mice correlated to suspected human schizophrenia risk factors, the researchers compared the genetic sequences of 2,961 schizophrenia patients and healthy people from Scotland, Germany and the United States. Specifically, they determined if specific variations of DNA letters found in two genes, DISC1 and a gene for another protein, NKCC1, which controls the effect of GABA, were more likely to be found in schizophrenia patients than in healthy individuals. They paired 36 DNA "letter" changes in DISC1 and two DNA letter variations in NKCC1 one DNA letter change per gene in all possible combinations. Results showed that if a person's genome contained one specific combination of single DNA letter changes, then that person is 1.4 times more likely than people without these DNA changes to develop schizophrenia. Having these single DNA letter changes in either one of these genes alone did not increase risk.

"Now that we have identified the precise genetic risks, we can rationally search for drugs that correct these defects," says Hongjun Song, Ph.D., co-author, professor of neurology and director of the Stem Cell Program at the Institute for Cell Engineering.

###

Other authors of the paper from Johns Hopkins are Ju Young Kim, Cindy Y. Liu, Fengyu Zhang, Xin Duan, Zhexing Wen, Juan Song, Kimberly Christian and Daniel R. Weinberger. Emer Feighery, Bai Lu and Joseph H. Callicott from the National Institute of Mental Health, Dan Rujescu of Ludwig-Maximilians-University, and David St Clair of the University of Aberdeen Royal Cornhill Hospital are additional authors.

The study was funded by the National Institutes of Health, the Maryland Stem Cell Research Foundation, the Brain and Behavior Research Foundation and the International Mental Health Research Organization.

Related Stories: Schizophrenia: Small Genetic Changes Pose Risk For Disease: http://www.hopkinsmedicine.org/news/media/releases/schizophrenia_small_genetic_changes_pose_risk_for_disease

Johns Hopkins Team Creates Stem Cells From Schizophrenia Patients: http://www.hopkinsmedicine.org/news/media/releases/johns_hopkins_team_creates_stem_cells_from_schizophrenia_patients

New "Schizophrenia Gene" Prompts Researchers To Test Potential Drug Target: http://www.hopkinsmedicine.org/news/media/releases/new_schizophrenia_gene_prompts_researchers_to_test_potential_drug_target

Normal Role for Schizophrenia Risk Gene Identified: http://www.hopkinsmedicine.org/news/media/releases/Normal_Role_for_Schizophrenia_Risk_Gene_Identified

On the Web: Hongjun Song: http://www.hopkinsmedicine.org/institute_cell_engineering/experts/hongjun_song.html

Guo-li Ming: http://www.hopkinsmedicine.org/institute_cell_engineering/experts/guo_ming.html

Institute for Cell Engineering: http://www.hopkinsmedicine.org/institute_cell_engineering/

Johns Hopkins Medicine
Media Relations and Public Affairs
Media Contacts:
Vanessa McMains; 410-502-9410; vmcmain1@jhmi.edu
Audrey Huang; 410-614-5105; audrey@jhmi.edu


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Genetic risk and stressful early infancy join to increase risk for schizophrenia [ Back to EurekAlert! ] Public release date: 26-Mar-2012
[ | E-mail | Share Share ]

Contact: Vanessa McMains
cmain1@jhmi.edu
410-502-9410
Johns Hopkins Medical Institutions

Human genome and mouse studies identify new precise genetic links

Working with genetically engineered mice and the genomes of thousands of people with schizophrenia, researchers at Johns Hopkins say they now better understand how both nature and nurture can affect one's risks for schizophrenia and abnormal brain development in general.

The researchers reported in the March 2 issue of Cell that defects in a schizophrenia-risk genes and environmental stress right after birth together can lead to abnormal brain development and raise the likelihood of developing schizophrenia by nearly one and half times.

"Our study suggests that if people have a single genetic risk factor alone or a traumatic environment in very early childhood alone, they may not develop mental disorders like schizophrenia," says Guo-li Ming, M.D., Ph.D., professor of neurology and member of the Institute for Cell Engineering at the Johns Hopkins University School of Medicine. "But the findings also suggest that someone who carries the genetic risk factor and experiences certain kinds of stress early in life may be more likely to develop the disease."

Pinpointing the cause or causes of schizophrenia has been notoriously difficult, owing to the likely interplay of multiple genes and environmental triggers, Ming says. Searching for clues at the molecular level, the Johns Hopkins team focused on the interaction of two factors long implicated in the disease: Disrupted-in-Schizophrenia 1 (DISC1) protein, which is important for brain development, and GABA, a brain chemical needed for normal brain function.

To find how these factors impact brain development and disease susceptibility, the researchers first engineered mice to have reduced levels of DISC1 protein in one type of neuron in the hippocampus, a region of the brain involved in learning, memory and mood regulation. Through a microscope, they saw that newborn mouse brain cells with reduced levels of DISC1 protein had similar sized and shaped neurons as those from mice with normal levels of DISC1 protein. To change the function of the chemical messenger GABA, the researchers engineered the same neurons in mice to have more effective GABA. Those brain cells looked much different than normal neurons, with longer appendages or projections. Newborn mice engineered with both the more effective GABA and reduced levels of DISC1 showed the longest projections, suggesting, Ming said, that defects in both DISC1 and GABA together could change the physiology of developing neurons for the worse.

Meanwhile, other researchers at University of Calgary and at the National Institute of Physiological Sciences in Japan had shown in newborn mice that changes in environment and routine stress can impede GABA from working properly during development. In the next set of experiments, the investigators paired reducing DISC1 levels and stress in mice to see if it could also lead to developmental defects. To stress the mice, the team separated newborns from their mothers for three hours a day for ten days, then examined neurons from the stressed newborns and saw no differences in their size, shape and organization compared with unstressed mice. But when they similarly stressed newborn mice with reduced DISC1 levels, the neurons they saw were larger, more disorganized and had more projections than the unstressed mouse neurons. The projections, in fact, went to the wrong places in the brain.

Next, to see if their results in mice correlated to suspected human schizophrenia risk factors, the researchers compared the genetic sequences of 2,961 schizophrenia patients and healthy people from Scotland, Germany and the United States. Specifically, they determined if specific variations of DNA letters found in two genes, DISC1 and a gene for another protein, NKCC1, which controls the effect of GABA, were more likely to be found in schizophrenia patients than in healthy individuals. They paired 36 DNA "letter" changes in DISC1 and two DNA letter variations in NKCC1 one DNA letter change per gene in all possible combinations. Results showed that if a person's genome contained one specific combination of single DNA letter changes, then that person is 1.4 times more likely than people without these DNA changes to develop schizophrenia. Having these single DNA letter changes in either one of these genes alone did not increase risk.

"Now that we have identified the precise genetic risks, we can rationally search for drugs that correct these defects," says Hongjun Song, Ph.D., co-author, professor of neurology and director of the Stem Cell Program at the Institute for Cell Engineering.

###

Other authors of the paper from Johns Hopkins are Ju Young Kim, Cindy Y. Liu, Fengyu Zhang, Xin Duan, Zhexing Wen, Juan Song, Kimberly Christian and Daniel R. Weinberger. Emer Feighery, Bai Lu and Joseph H. Callicott from the National Institute of Mental Health, Dan Rujescu of Ludwig-Maximilians-University, and David St Clair of the University of Aberdeen Royal Cornhill Hospital are additional authors.

The study was funded by the National Institutes of Health, the Maryland Stem Cell Research Foundation, the Brain and Behavior Research Foundation and the International Mental Health Research Organization.

Related Stories: Schizophrenia: Small Genetic Changes Pose Risk For Disease: http://www.hopkinsmedicine.org/news/media/releases/schizophrenia_small_genetic_changes_pose_risk_for_disease

Johns Hopkins Team Creates Stem Cells From Schizophrenia Patients: http://www.hopkinsmedicine.org/news/media/releases/johns_hopkins_team_creates_stem_cells_from_schizophrenia_patients

New "Schizophrenia Gene" Prompts Researchers To Test Potential Drug Target: http://www.hopkinsmedicine.org/news/media/releases/new_schizophrenia_gene_prompts_researchers_to_test_potential_drug_target

Normal Role for Schizophrenia Risk Gene Identified: http://www.hopkinsmedicine.org/news/media/releases/Normal_Role_for_Schizophrenia_Risk_Gene_Identified

On the Web: Hongjun Song: http://www.hopkinsmedicine.org/institute_cell_engineering/experts/hongjun_song.html

Guo-li Ming: http://www.hopkinsmedicine.org/institute_cell_engineering/experts/guo_ming.html

Institute for Cell Engineering: http://www.hopkinsmedicine.org/institute_cell_engineering/

Johns Hopkins Medicine
Media Relations and Public Affairs
Media Contacts:
Vanessa McMains; 410-502-9410; vmcmain1@jhmi.edu
Audrey Huang; 410-614-5105; audrey@jhmi.edu


[ Back to EurekAlert! ] [ | E-mail | Share Share ]

?


AAAS and EurekAlert! are not responsible for the accuracy of news releases posted to EurekAlert! by contributing institutions or for the use of any information through the EurekAlert! system.


Source: http://www.eurekalert.org/pub_releases/2012-03/jhmi-gra032612.php

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Smash ? Just Only Love

26 Mar

I would like to introduce this new TV series SMASH. Though just 7 ep till now but I LOVE IT! Ok, I think cause I love musical, so I love any shows with music. For example, Glee?s storyline sucks, but I continue to watch it cause of the songs. And Smash is an entirely different show compared to Glee. It?s more like a broadway musical about Marilyn Monroe, more adult-ly cause of the politics, relationships, affairs and etc. I really love Smash! And I like Katherine McPhee?s voice!

Like this:

2 bloggers like this post.

Source: http://lijietan.wordpress.com/2012/03/26/smash/

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Prostate Cancer Symptoms ? Cute Girl Hair Color Spa

Only couple of people of today come to know about the symptoms of prostate cancer. This sort of cancer occurs only in men. They are growing day-to-day amongst them. It is meticulously considered as the main trigger for death in males. In the starting stage, this disease can?t be traced out. When the condition is diagnosed, at that time, the disease has spread all over the body. It can be really vital for you to have knowledge of prostate cancer symptoms to ensure that it is possible to stop within the beginning stage.

This illness affects the overall health of all individuals. It reduces the degree of energy, social life, and sexual life of an individual. If you?re familiar with the prostate cancer symptoms, you must consult the physician to take therapy for this dreadful disease surely with no fail. Just as with other cancers, this illness is really dangerous also life-threatening.

Prostate cancer has numerous symptoms like other diseases. Commonly, men with age group of a lot more than 50 years are suffering with this type of cancer. Couple of prostate cancer symptoms are given beneath for you to know concerning the deadly disease in the early stage.

1. Troubles during urination

The initial widespread symptom is troubles in the course of urination. You might have to check with these troubles. There will likely be extremely difficulty while passing urine due to the fact that the bladder plus the prostate are close together. Thus, the tumors arise within the part of prostate after which push the bladder; hence, there will likely be difficulty when passing urine.

2. Existence of Blood in the urine

The second symptom is that existence of blood within the urine. Should you see blood after you are passing urine then you have to consult your family members and physician instantly with out delaying. You can not guess that it is a cancer; it may also due to other infections. Eventhough, you need to take care of one?s medical checkup inside the beginning stage.

3. Troubles during erection

Prostate cancer also affects sexual also private life simply because it troubles in the course of erection. There will likely be lack of ability for sustaining and getting an erection. Often, you can have painful ejaculation. Prostate is significant portion of reproductive program of men. If this difficulty persists for you, it will be very hard in your sexual life. It affects the sex organ.

4. Swelling inside your legs

Those who are suffering with prostate cancer, surely, there might be swelling within the legs. You need to notice this as one of the symptoms. This illness spreads to the entire lymph nodes. As a result of this, there is going to be swelling inside your legs. Often, your hips as well as buttocks also get severe pain. Due to this trigger, there will likely be swelling inside your legs.

5. Discomfort in the pelvic region

You will have severe pain as well as discomfort inside the location of pelvic. This occurs due to lymph nodes. The lymph node presses the location of pelvic and causes severe pain.

Therefore, to avoid from the disease prostate cancer, it is best to have information of the symptoms. Should you see any of the symptom given in this article, you instantly see the doctor. Then, only the physician will diagnose and let you know concerning the difficulty, and you can start the remedy in advance just before the diseases worsened.

This article above may have answered some of your questions on this issue but if you want to learn more please go to Prostate Cancer Symptoms or you might be more interested on Prostate Cancer Facts.

Source: http://cghaircolorspa.info/prostate-cancer-symptoms?utm_source=rss&utm_medium=rss&utm_campaign=prostate-cancer-symptoms

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Corporate and Finance news and Tips ? Understanding Credit and ...

March 27th, 2012

Posted by : admin

Debts are of two types that is secured and unsecured. Secured debts are those which are attached to some asset like car for car loan and house for house loan. In this case the lender can sell the asset to procure the loan. However, the unsecured debts include credit cards, medical bills and signature loan. These loans are not attached to any asset and hence difficult to procure.

There are some warning signs to tell that the debt is going out of hand and need to be managed. These are when you are only able to pay the minimum payments for your loan or any other debt, you resort to buying new credit cards to pay of the bills of old card, thus you keep rotating but do not retire. It?s a great warning sign if you have reached the limit of your credit and account and at the same time listed as having bad credit history. Always follow 20/10 rule which says never take loan greater than 20% and monthly payment more than 10% of your income.

Source: http://www.corporate2.com/understanding-credit-and-debt/

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Economics of Entrepreneurialism, Wealth and Globalization


The Economics of Entrepreneurialism, Wealth and Globalization

Presented by:

Congressman Mike Doyle, 14th Congressional District of Pennsylvania

Allegheny County Chief Executive, Rich Fitzgerald

Charlie Batch, Founder of Best of the Batch Foundation, Pittsburgh Steelers QB

Economic Development Administration, U.S. Department of Commerce

Center for Faith-Based and Neighborhood Partnerships, U.S. Department of Commerce

Small Business Administration, Washington D.C.

Allegheny County Department of Minority, Women and Disadvantaged Business Enterprise

Christian Evangelistic Economic Development

Christian Management Enterprises, LLC

Please join us on

Friday, March 30, 2012, 8:00 AM ? 12:00 PM

at the Hosanna House

807 Wallace Avenue

Wilkinsburg, PA 15221

8:00 AM Registration and Breakfast

8:30 AM ? 12:00 PM Guest Speakers and Small Business Networking Mixer

Break-Out Sessions and Faith-Based Round Table Discussion

Break-Out Sessions Include:

First National Bank: How to Secure Bank Financing for your Small Business

CEED: Skills to Wealth Small Business Assistance Information Session

Allegheny County M/W/DBE: How to do Business with the County

Economic Development Administration: Key Priorities and Accessing Funding

Speakers Include:

Dr. Howard B. Slaughter, JR., CEO, Christian Management Enterprises, LLC

Bishop Loran E. Mann, Prelate, Vermont Ecclesiastical Jurisdiction (Opening Prayer)

John Thompson, Mayor of Wilkinsburg (Welcome)

Congressman Mike Doyle, 14th Congressional District of Pennsylvania

Charlie Batch, Founder of Best of the Batch Foundation, Pittsburgh Steelers QB

Rich Fitzgerald, Allegheny County Chief Executive

Ruth Byrd-Smith, Director, M/W/DBE Department of Allegheny County

Willie C. Taylor, Regional Director, Economic Development Administration, U.S. Department of Commerce

Cedric Grant, Director, Center for Faith-Based and Neighborhood Partnerships, U.S. Department of Commerce

Jerry Flavin, Small Business Administration, Washington D.C

Rufus Idris, Executive Director, Christian Evangelistic Economic Development

This event is free and open to the Public

There will be light refreshments and an International Dance Performance

Please RSVP to CEED by Monday, March 19th

Email: info@usaceed.org

412.450.8070

Posted on behalf of Dreamweaver Marketing Associates.? Joyce Kane is the owner of Cybertary Pittsburgh, a Virtual Administrative support company, providing virtual office support, personal and executive assistance, creative design services and light bookkeeping.? Cybertary works with businesses and busy individuals to help them work 'on' their business rather than 'in' their business.? www.Cybertary.com/Pittsburgh

Source: http://dreamweavermarketingassociates.blogspot.com/2012/03/economics-of-entrepreneurialism-wealth.html

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